Thursday, April 5, 2012

ANTIGOUT DRUGS



COLCHICINE

·         An anti-inflammatory drug that inhibits the migration of leukocytes to the inflamed site.
·         It is a potent medication in alleviating acute symptoms of gout
·         Colchicine does NOT inhibit uric acid synthesis and does NOT promote uric acid excretion.
·         Contraindication: severe renal, cardiac and renal disorders

Side effects:

Gastric irritation
Diarrhea
Nausea & vomiting
Abdominal pain

ALLOPURINOL (Zyloprim®)

·         It inhibits the final steps of uric acid biosynthesis thus lower serum uric acid levels.
·         The drug of choice for patient with chronic tophaceous gout
·         This agent is also prescribed for patient with leukemia and polycythemia vera.

URICOSURICS
probenecid (Benemid®); sulfinpyrazone (Anturane®)

·         Uricosuric medication induces increase rate of uric acid excretion by inhibiting reabsorption.
·         This has shown effectiveness in alleviating chronic gout.



Nursing consideration:

ü  Advise patient to take drugs with food and/or antacids to prevent gastric irritation.
ü  Inform patient to increase fluid intake to promote diuresis and prevent alkalinization of the urine due to allopurinol medication.
ü  Probenecid should not be used during acute attacks of gout.
ü  Aspirin use should be avoided because it causes uric acid retention.
ü  Suggest to patient not to take vitamin C while taking alluporinol

1 comment:

  1. Good sharing. I read an article title “To Those Having Gout Problem” mentioned that a special gout remedy call gout papaya green tea and it's extremely good to help cure gout issue. See the article at:
    http://kidbuxblog.com/to-those-having-gout-problem/

    ReplyDelete